{"id":2598,"date":"2023-12-01T18:00:00","date_gmt":"2023-12-01T10:00:00","guid":{"rendered":"https:\/\/www.junshipharma.com\/?p=2598"},"modified":"2024-04-09T15:47:46","modified_gmt":"2024-04-09T07:47:46","slug":"%e6%be%b3%e5%a4%a7%e5%88%a9%e4%ba%9e%e8%97%a5%e5%93%81%e7%ae%a1%e7%90%86%e5%b1%80%e5%8f%97%e7%90%86%e7%89%b9%e7%91%9e%e6%99%ae%e5%88%a9%e5%96%ae%e6%8a%97%e4%b8%8a%e5%b8%82%e8%a8%b1%e5%8f%af%e7%94%b3","status":"publish","type":"post","link":"https:\/\/www.junshipharma.com\/zh-hant\/%e6%be%b3%e5%a4%a7%e5%88%a9%e4%ba%9e%e8%97%a5%e5%93%81%e7%ae%a1%e7%90%86%e5%b1%80%e5%8f%97%e7%90%86%e7%89%b9%e7%91%9e%e6%99%ae%e5%88%a9%e5%96%ae%e6%8a%97%e4%b8%8a%e5%b8%82%e8%a8%b1%e5%8f%af%e7%94%b3\/","title":{"rendered":"\u6fb3\u5927\u5229\u4e9e\u85e5\u54c1\u7ba1\u7406\u5c40\u53d7\u7406\u7279\u745e\u666e\u5229\u55ae\u6297\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb"},"content":{"rendered":"\n
\u5317\u4eac\u6642\u95932023\u5e7412\u67081\u65e5\uff0c\u541b\u5be6\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u5ba3\u4f48\uff0c\u7531\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u6297PD-1\u55ae\u6297\u85e5\u7269\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u9806\u9251\/\u5409\u897f\u4ed6\u6ff1\u4f5c\u70ba\u8f49\u79fb\u6027\u6216\u5fa9\u767c\u6027\u5c40\u90e8\u665a\u671f\u9f3b\u54bd\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff0c\u4ee5\u53ca\u4f5c\u70ba\u55ae\u85e5\u6cbb\u7642\u65e2\u5f80\u542b\u9251\u6cbb\u7642\u904e\u7a0b\u4e2d\u6216\u6cbb\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684\u5fa9\u767c\u6027\u3001\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u7684\u6210\u4eba\u60a3\u8005\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\u5df2\u65bc\u8fd1\u65e5\u7372\u5f97\u6fb3\u5927\u5229\u4e9e\u85e5\u54c1\u7ba1\u7406\u5c40\uff08TGA\uff09\u53d7\u7406\u3002\u6b64\u5916\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u7528\u65bc\u6cbb\u7642\u9f3b\u54bd\u764c\u9084\u7372\u5f97\u4e86TGA\u6388\u4e88\u7684\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002<\/p>\n\n\n\n
\u672c\u6b21\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\u7684\u905e\u4ea4\u662f\u901a\u904e\u5967\u6bd4\u65af\u5c08\u6848\uff08Project Orbis\uff09\u3002Project Orbis\u7531FDA\u816b\u7624\u5b78\u5353\u8d8a\u4e2d\u5fc3\uff08OCE\uff09\u767c\u8d77\u548c\u5ba3\u5c0e\uff0c\u70baFDA\u548c\u5176\u5b83\u570b\u5bb6\u53ca\u5730\u5340\u7684\u76e3\u7ba1\u6a5f\u69cb\u642d\u5efa\u5408\u4f5c\u6a5f\u5236\u548c\u6846\u67b6\uff0c\u5141\u8a31\u4e0d\u540c\u76e3\u7ba1\u6a5f\u69cb\u5171\u540c\u5be9\u8a55\u816b\u7624\u85e5\u54c1\u7684\u8a3b\u518a\u7533\u8acb\uff0c\u76ee\u524d\u5df2\u6709TGA\u3001\u65b0\u52a0\u5761\u885b\u751f\u79d1\u5b78\u5c40\uff08HSA\uff09\u3001\u52a0\u62ff\u5927\u885b\u751f\u90e8\uff08HC\uff09\u3001\u82f1\u570b\u85e5\u54c1\u548c\u4fdd\u5065\u54c1\u7ba1\u7406\u5c40\uff08MHRA\uff09\u7b49\u53e6\u59167\u5bb6\u76e3\u7ba1\u6a5f\u69cb\u53c3\u8207\u3002\u7533\u8acbProject Orbis\u7684\u85e5\u7269\uff0c\u5176\u9069\u61c9\u75c7\u5fc5\u9808\u70ba\u816b\u7624\u985e\u75be\u75c5\u3002\u4e00\u822c\u60c5\u6cc1\u4e0b\uff0c\u8a72\u7533\u8acb\u61c9\u7b26\u5408FDA\u512a\u5148\u5be9\u8a55\u7684\u6a19\u6e96\uff0c\u5373\u85e5\u7269\u65e8\u5728\u6cbb\u7642\u56b4\u91cd\u75be\u75c5\u4e26\u4e14\u85e5\u7269\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0c\u5c07\u986f\u8457\u63d0\u9ad8\u6cbb\u7642\u7684\u5b89\u5168\u6027\u6216\u6709\u6548\u6027\uff0c\u4e26\u4e14\u85e5\u7269\u672c\u8eab\u6709\u8f03\u5927\u7684\u5f71\u97ff\u529b\u548c\u91cd\u5927\u7684\u81e8\u5e8a\u512a\u52e2\u3002\u5728Project Orbis\u7684\u5de5\u4f5c\u6846\u67b6\u4e0b\uff0c\u570b\u969b\u76e3\u7ba1\u6a5f\u69cb\u9593\u7684\u5408\u4f5c\u6709\u52a9\u65bc\u816b\u7624\u60a3\u8005\u66f4\u65e9\u5730\u7372\u5f97\u4f86\u81ea\u5176\u4ed6\u570b\u5bb6\u7684\u65b0\u7642\u6cd5\u3002<\/p>\n\n\n\n
\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u9f3b\u54bd\u764c\u9069\u61c9\u75c7\u7b26\u5408\u8a72\u7533\u8acb\u6a19\u6e96\uff0c\u662f\u9996\u500b\u88ab\u7d0d\u5165Project Orbis\u7684\u570b\u7522\u816b\u7624\u85e5\uff0c\u541b\u5be6\u751f\u7269\u5c07\u5728\u591a\u500b\u9069\u7528\u8a72\u8def\u5f91\u7684\u570b\u5bb6\u548c\u5730\u5340\u63a2\u7d22\u5feb\u901f\u4e0a\u5e02\u7684\u53ef\u80fd\u3002<\/p>\n\n\n\n
\u672c\u6b21\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\u4e3b\u8981\u57fa\u65bcJUPITER-02\uff08\u4e00\u9805\u91dd\u5c0d\u4e00\u7dda\u6cbb\u7642\u9f3b\u54bd\u764c\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u570b\u969b\u591a\u4e2d\u5fc3III\u671f\u81e8\u5e8a\u7814\u7a76\uff0cNCT03581786\uff09\u53caPOLARIS-02\uff08\u4e00\u9805\u91dd\u5c0d\u4e8c\u7dda\u53ca\u4ee5\u4e0a\u6cbb\u7642\u7684\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u7684\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c64\u3001II\u671f\u95dc\u9375\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff0cNCT02915432\uff09\u7684\u7814\u7a76\u7d50\u679c\u3002<\/p>\n\n\n\n
JUPITER-02\u7814\u7a76\u662f\u9f3b\u54bd\u764c\u514d\u75ab\u6cbb\u7642\u9818\u57df\u9996\u500b\u570b\u969b\u591a\u4e2d\u5fc3\u3001\u6a23\u672c\u91cf\u6700\u5927\u7684\u96d9\u76f2\u3001\u96a8\u6a5f\u5c0d\u7167\u2162\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u5176\u7814\u7a76\u6210\u679c\u5148\u5f8c\u57282021\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u5168\u9ad4\u5927\u6703\uff08#LBA2\uff09\u3001\u300a\u81ea\u7136-\u91ab\u5b78\u300b\uff08Nature Medicine<\/em>\uff0c\u5f71\u97ff\u56e0\u5b50\uff1a82.9\uff09\u3001\u300a\u7f8e\u570b\u91ab\u5b78\u6703\u96dc\u8a8c\u300b\uff08JAMA<\/em>\uff0c\u5f71\u97ff\u56e0\u5b50\uff1a120.7\uff09\u767c\u8868\u3002\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0c\u8207\u55ae\u7d14\u5316\u7642\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u4e00\u7dda\u6cbb\u7642\u5fa9\u767c\/\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u53ef\u986f\u8457\u5ef6\u9577\u60a3\u8005\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\uff0c\u4f7f\u60a3\u8005\u7684\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e48%\uff0c\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e37%\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u53ef\u63a7\u3002<\/p>\n\n\n\n POLARIS-02\u7814\u7a76\u7d50\u679c\u5df2\u65bc2021\u5e741\u6708\u7dda\u4e0a\u767c\u8868\u65bc\u300a\u81e8\u5e8a\u816b\u7624\u5b78\u96dc\u8a8c\u300b\uff08Journal of Clinical Oncology<\/em>\uff0c\u5f71\u97ff\u56e0\u5b50\uff1a45.3\uff09\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u5728\u65e2\u5f80\u5316\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u4e2d\u8868\u73fe\u51fa\u6301\u4e45\u7684\u6297\u816b\u7624\u6d3b\u6027\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u60a3\u8005\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba20.5%\uff0c\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08DoR\uff09\u70ba12.8\u500b\u6708\uff0c\u4e2d\u4f4dOS\u905417.4\u500b\u6708\u3002<\/p>\n\n\n\n \u622a\u81f3\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u5df2\u5728\u4e2d\u570b\u7372\u62796\u9805\u9069\u61c9\u75c7\uff0c\u53e6\u67094\u9805\u9069\u61c9\u75c7\u7684\u4e0a\u5e02\u7533\u8acb\u6b63\u5728\u63a5\u53d7\u76e3\u7ba1\u6a5f\u69cb\u5be9\u8a55\uff1b\u5728\u570b\u969b\u4e0a\uff0c\u8a72\u7522\u54c1\u5df2\u5728\u7f8e\u570b\u7372\u62792\u9805\u9f3b\u54bd\u764c\u9069\u61c9\u75c7\uff0c\u53e6\u67092\u9805\u9069\u61c9\u75c7\uff08\u98df\u7ba1\u764c\u548c\u9f3b\u54bd\u764c\uff09\u7684\u4e0a\u5e02\u7533\u8acb\u6b63\u5728\u63a5\u53d7\u6b50\u76df\u548c\u82f1\u570b\u76e3\u7ba1\u6a5f\u69cb\u7684\u5be9\u8a55\u3002<\/p>\n\n\n\n \u95dc\u65bc\u9f3b\u54bd\u764c<\/strong><\/p>\n\n\n\n \u9f3b\u54bd\u764c\u662f\u4e00\u7a2e\u767c\u751f\u65bc\u9f3b\u54bd\u90e8\u9ecf\u819c\u4e0a\u76ae\u7684\u60e1\u6027\u816b\u7624\uff0c\u662f\u5e38\u898b\u7684\u982d\u9838\u90e8\u60e1\u6027\u816b\u7624\u4e4b\u4e00\u3002\u64da\u4e16\u754c\u885b\u751f\u7d44\u7e54\u7d71\u8a08\uff0c2020\u5e74\u9f3b\u54bd\u764c\u5728\u5168\u7403\u7bc4\u570d\u5167\u78ba\u8a3a\u7684\u65b0\u767c\u75c5\u4f8b\u6578\u8d85\u904e13\u842c1<\/sup>\u3002\u7531\u65bc\u539f\u767c\u816b\u7624\u4f4d\u7f6e\u7684\u539f\u56e0\uff0c\u5f88\u5c11\u63a1\u7528\u624b\u8853\u6cbb\u7642\uff0c\u91dd\u5c0d\u5c40\u9650\u6027\u764c\u75c7\u4e3b\u8981\u63a1\u7528\u653e\u7642\u6216\u653e\u5316\u7642\u7d50\u5408\u9032\u884c\u6cbb\u7642\u3002<\/p>\n\n\n\n <\/p>\n","protected":false},"excerpt":{"rendered":" \u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u9806\u9251\/\u5409\u897f\u4ed6\u6ff1\u4f5c\u70ba\u8f49\u79fb\u6027\u6216\u5fa9\u767c\u6027\u5c40\u90e8\u665a\u671f\u9f3b\u54bd\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff0c\u4ee5\u53ca\u4f5c\u70ba\u55ae\u85e5\u6cbb\u7642\u65e2\u5f80\u542b\u9251\u6cbb\u7642\u904e\u7a0b\u4e2d\u6216\u6cbb\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684\u5fa9\u767c\u6027\u3001\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u7684\u6210\u4eba\u60a3\u8005\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\u5df2\u65bc\u8fd1\u65e5\u7372\u5f97\u6fb3\u5927\u5229\u4e9e\u85e5\u54c1\u7ba1\u7406\u5c40\uff08TGA\uff09\u53d7\u7406<\/p>\n","protected":false},"author":3,"featured_media":1115,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21],"tags":[],"class_list":["post-2598","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-21"],"yoast_head":"\n\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n
1. https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/4-Nasopharynx-fact-sheet.pdf.<\/h5>\n\n\n\n