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Medicine<\/em>\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a58.7\uff09\u6742\u5fd7\u5c01\u9762\uff0c\u5e76\u83b7\u5f97\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\u300b\uff08<em>Journal of the American Medical Association<\/em>\uff0c<em>JAMA<\/em>\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a63.1\uff09\u5168\u6587\u53d1\u8868\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5355\u7eaf\u5316\u7597\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u4f7f\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55\u98ce\u9669\u964d\u4f4e48%\uff0c\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e37%\u3002\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5bf9\u6bd4\u5355\u7eaf\u5316\u7597\u5ef6\u957f\u4e8613.2\u4e2a\u6708\uff0c\u4ece8.2\u4e2a\u6708\u63d0\u5347\u523021.4\u4e2a\u6708\u3002\u6b64\u5916\uff0c\u63a5\u53d7\u8be5\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u7684\u60a3\u8005\u53ef\u83b7\u5f97\u66f4\u9ad8\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff0c\u66f4\u957f\u7684\u6301\u7eed\u7f13\u89e3\u65f6\u95f4\uff08DoR\uff09\u548c\u66f4\u9ad8\u7684\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\uff0c\u4e14\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002\u957f\u671f\u751f\u5b58\u968f\u8bbf\u6570\u636e\u57282024\u5e74ASCO\u5e74\u4f1a\u5c55\u793a\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u6cbb\u7597\u7ec45\u5e74\u751f\u5b58\u7387\u8fbe\u523052.0%\u3002<\/p>\n\n\n\n<p>\u57fa\u4e8e\u8be5\u9879\u7814\u7a76\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u5206\u522b\u4e8e2021\u5e74\u548c2023\u5e74\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u548c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u7528\u4e8e\u665a\u671f\u9f3b\u54bd\u764c\u7684\u6cbb\u7597\uff0c\u662f\u5168\u7403\u9996\u4e2a\u83b7\u6279\u9f3b\u54bd\u764c\u6cbb\u7597\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u836f\u7269\uff0c\u4e5f\u662f\u7f8e\u56fd\u9996\u4e2a\u4e14\u552f\u4e00\u7528\u4e8e\u9f3b\u54bd\u764c\u6cbb\u7597\u7684\u836f\u7269\u3002\u6b64\u5916\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7528\u4e8e\u6cbb\u7597NPC\u76f8\u5173\u9002\u5e94\u75c7\u7684\u4e0a\u5e02\u7533\u8bf7\u6b63\u5728\u540c\u6b65\u63a5\u53d7\u82f1\u56fd\u836f\u54c1\u548c\u4fdd\u5065\u54c1\u7ba1\u7406\u5c40\uff08MHRA\uff09\u3001\u6fb3\u5927\u5229\u4e9a\u836f\u54c1\u7ba1\u7406\u5c40\uff08TGA\uff09\u3001\u65b0\u52a0\u5761\u536b\u751f\u79d1\u5b66\u5c40\uff08HSA\uff09\u4ee5\u53ca\u4e2d\u56fd\u9999\u6e2f\u536b\u751f\u7f72\u836f\u7269\u529e\u516c\u5ba4\uff08DO\uff09\u7b49\u56fd\u5bb6\u548c\u5730\u533a\u76d1\u7ba1\u673a\u6784\u7684\u5ba1\u8bc4\u3002<\/p>\n\n\n\n<p>JUPITER-06\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff08NCT03829969\uff09\uff0c\u65e8\u5728\u8bc4\u4f30\u4e0e\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u7d2b\u6749\u9187\/\u987a\u94c2\uff08TP\uff09\u7528\u4e8e\u665a\u671fESCC\u4e00\u7ebf\u6cbb\u7597\u7684\u7597\u6548\u53ca\u5b89\u5168\u6027\u3002\u8be5\u7814\u7a76\u7ed3\u679c\u9996\u6b21\u5728\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u5e74\u4f1a\uff08ESMO 2021\uff09\u4e0a\u4ee5\u53e3\u5934\u6c47\u62a5\u5f62\u5f0f\u62a5\u544a\uff0c\u968f\u540e\u5728\u56fd\u9645\u9876\u5c16\u80bf\u7624\u5b66\u6742\u5fd7\u300a<em>Cancer Cell<\/em>\u300b\uff08\u5f71\u54cd\u56e0\u5b50\uff1a48.8\uff09\u548c\u300a\u4e34\u5e8a\u80bf\u7624\u5b66\u6742\u5fd7\u300b\uff08<em>Journal of Clinical Oncology<\/em>\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a42.1\uff09\u53d1\u8868\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u53ef\u4f7f\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u83b7\u5f97\u66f4\u4f18\u7684PFS\u548cOS\uff0c\u5176\u4e2d\u4e2d\u4f4dOS\u5ef6\u957f6\u4e2a\u6708\uff0c\u8fbe\u523017\u4e2a\u6708\uff0c\u5e76\u663e\u8457\u964d\u4f4e\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u8fbe42%\uff0c\u663e\u8457\u6539\u5584\u751f\u5b58\u83b7\u76ca\uff0c\u4e14\u65e0\u8bbaPD-L1\u8868\u8fbe\u5982\u4f55\u5747\u53ef\u83b7\u76ca\u3002<\/p>\n\n\n\n<p>\u57fa\u4e8e\u8be5\u9879\u7814\u7a76\uff0c2022\u5e745\u6708\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7528\u4e8e\u6cbb\u7597ESCC\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u5728\u4e2d\u56fd\u83b7\u6279\u3002\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597ESCC\u7684\u4e0a\u5e02\u7533\u8bf7\u6b63\u5728\u63a5\u53d7MHRA\u7684\u5ba1\u8bc4\u3002<\/p>\n\n\n\n<p><strong>JUPITER-02\u3001JUPITER-06\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f90\u745e\u534e\u6559\u6388<\/strong>\u8868\u793a\uff1a\u201c\u9f3b\u54bd\u764c\u548c\u98df\u7ba1\u764c\u90fd\u5177\u6709\u4e9a\u6d32\u533a\u57df\u9ad8\u53d1\u7684\u7279\u70b9\uff0c\u6b27\u7f8e\u56fd\u5bb6\u5728\u6b64\u7c7b\u7624\u79cd\u9886\u57df\u7684\u521b\u65b0\u7597\u6cd5\u5f00\u53d1\u65b9\u9762\u8f83\u4e3a\u7f13\u6162\u3002JUPITER-02\u548cJUPITER-06\u7814\u7a76\u7684\u51fa\u8272\u7684\u7814\u7a76\u6210\u679c\u8bc1\u660e\u4e86\u5728\u9f3b\u54bd\u764c\u548c\u98df\u7ba1\u764c\u9886\u57df\uff0c\u4e2d\u56fd\u5b66\u8005\u7684\u8bca\u7597\u80fd\u529b\u548c\u4e34\u5e8a\u79d1\u7814\u6c34\u5e73\u5df2\u7ecf\u4f4d\u5217\u5168\u7403\u9886\u5148\uff0c\u671f\u5f85\u8fd9\u9879\u2018\u4e2d\u56fd\u65b9\u6848\u2019\u80fd\u591f\u5207\u5b9e\u6539\u53d8\u56fd\u9645\u4e0a\u7f79\u60a3\u8fd9\u4e24\u7c7b\u7624\u79cd\u4e14\u7f3a\u4e4f\u6709\u6548\u6cbb\u7597\u624b\u6bb5\u7684\u60a3\u8005\u5883\u9047\uff0c\u4e3a\u4ed6\u4eec\u5e26\u6765\u66f4\u597d\u7684\u751f\u5b58\u5e0c\u671b\uff01\u201d<\/p>\n\n\n\n<p><strong>\u541b\u5b9e\u751f\u7269\u603b\u7ecf\u7406\u517c\u9996\u5e2d\u6267\u884c\u5b98\u90b9\u5efa\u519b\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u2018\u7acb\u8db3\u4e2d\u56fd\uff0c\u5e03\u5c40\u5168\u7403\u2019\u662f\u541b\u5b9e\u751f\u7269\u521b\u7acb\u4e4b\u521d\u5373\u786e\u7acb\u7684\u6218\u7565\u53d1\u5c55\u76ee\u6807\uff0c\u6b64\u6b21\u7279\u745e\u666e\u5229\u5355\u6297\u83b7\u5f97EC\u6279\u51c6\uff0c\u610f\u5473\u7740\u7ee7\u4e2d\u56fd\u3001\u7f8e\u56fd\u4e4b\u540e\uff0c\u6211\u4eec\u5168\u7403\u5546\u4e1a\u5316\u5e03\u5c40\u7684\u811a\u6b65\u6b63\u5f0f\u8fc8\u5411\u6b27\u6d32\uff0c\u4e5f\u6807\u5fd7\u7740\u6211\u4eec\u5728\u521b\u65b0\u836f\u7684\u7814\u53d1\u548c\u751f\u4ea7\u8d28\u91cf\u518d\u6b21\u83b7\u5f97\u56fd\u9645\u6743\u5a01\u76d1\u7ba1\u673a\u6784\u7684\u8ba4\u53ef\u3002\u672a\u6765\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u643a\u624b\u5408\u4f5c\u4f19\u4f34\uff0c\u5168\u529b\u63a8\u52a8\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u6b27\u6d32\u5730\u533a\u7684\u5546\u4e1a\u5316\u843d\u5730\uff0c\u4e3a\u66f4\u591a\u6d77\u5916\u60a3\u8005\u63d0\u4f9b\u6765\u81ea\u4e2d\u56fd\u7684\u9ad8\u8d28\u91cf\u521b\u65b0\u836f\u7269\u3002\u201c<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><em>1. <\/em><em>\u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><em>2. <\/em><em>\u82e5\u60a8\u60f3\u4e86\u89e3\u5177\u4f53\u75be\u75c5\u8bca\u7597\u4fe1\u606f\uff0c\u8bf7\u9075\u4ece\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u4e0e\u6307\u5bfc\u3002<\/em><\/h5>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>\u5173\u4e8e\u9f3b\u54bd\u764c<\/strong><\/p>\n\n\n\n<p>\u9f3b\u54bd\u764c\u662f\u4e00\u79cd\u53d1\u751f\u4e8e\u9f3b\u54bd\u90e8\u9ecf\u819c\u4e0a\u76ae\u7684\u6076\u6027\u80bf\u7624\uff0c\u662f\u5e38\u89c1\u7684\u5934\u9888\u90e8\u6076\u6027\u80bf\u7624\u4e4b\u4e00\u3002\u6839\u636eGLOBOCAN 2022\u53d1\u5e03\u7684\u6570\u636e\u663e\u793a\uff0c2022\u5e74\u9f3b\u54bd\u764c\u5728\u5168\u7403\u8303\u56f4\u5185\u786e\u8bca\u7684\u65b0\u53d1\u75c5\u4f8b\u6570\u8d85\u8fc712\u4e07<sup>1<\/sup>\u3002\u7531\u4e8e\u539f\u53d1\u80bf\u7624\u4f4d\u7f6e\u7684\u539f\u56e0\uff0c\u5f88\u5c11\u91c7\u7528\u624b\u672f\u6cbb\u7597\u3002\u65b0\u8fd1\u66f4\u65b0\u7684ESMO\u6307\u5357\u63a8\u8350\u514d\u75ab\u6cbb\u7597\u8054\u5408\u5316\u7597\u7528\u4e8e\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u7684\u4e00\u7ebf\u6cbb\u7597<sup>2<\/sup>\u3002<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">\u3010\u53c2\u8003\u6587\u732e\u3011<\/h6>\n\n\n\n<h6 class=\"wp-block-heading\">1.<a href=\"https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/160-china-fact-sheet.pdf\">https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/160-china-fact-sheet.pdf<\/a>.<\/h6>\n\n\n\n<h6 class=\"wp-block-heading\">2.Bossi, P; Chan, AT; Even, C; Machiels, JP, et al.ESMO-EURACAN Clinical Practice Guideline update for nasopharyngeal carcinoma: adjuvant therapy and first-line treatment of recurrent\/metastatic disease. Ann Oncol, 2023; 34 (3): 247.<\/h6>\n\n\n\n<p><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><\/li>\n<\/ol>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>\u5173\u4e8e\u98df\u7ba1\u764c<\/strong><\/p>\n\n\n\n<p>\u98df\u7ba1\u764c\u662f\u6d88\u5316\u9053\u9886\u57df\u6700\u5e38\u89c1\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\u3002\u6839\u636eGLOBOCAN 2022\u53d1\u5e03\u7684\u6570\u636e\u663e\u793a\uff0c\u98df\u7ba1\u764c\u662f2022\u5e74\u5168\u7403\u7b2c\u5341\u4e00\u5927\u5e38\u89c1\u6076\u6027\u80bf\u7624\u548c\u7b2c\u4e03\u5927\u764c\u75c7\u6b7b\u4ea1\u539f\u56e0\uff0c\u65b0\u53d1\u75c5\u4f8b\u6570\u8d85\u8fc751.1\u4e07\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u6570\u8d85\u8fc744.5\u4e07<sup>1<\/sup>\u3002\u98df\u7ba1\u9cde\u764c\uff08ESCC\uff09\u548c\u817a\u764c\u662f\u98df\u7ba1\u764c\u7684\u4e24\u79cd\u4e3b\u8981\u7ec4\u7ec7\u5b66\u4e9a\u578b\u3002ESMO\u6307\u5357\u63a8\u8350PD-1\u963b\u65ad\u6027\u6297\u4f53\u8054\u5408\u5316\u7597\u7528\u4e8ePD-L1\u8868\u8fbe\u9633\u6027\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u7684\u4e00\u7ebf\u6cbb\u7597<sup>2<\/sup>\u3002<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">\u3010\u53c2\u8003\u6587\u732e\u3011<\/h6>\n\n\n\n<h6 class=\"wp-block-heading\">1.https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/160-china-fact-sheet.pdf.<\/h6>\n\n\n\n<h6 class=\"wp-block-heading\">2.Obermannova R,Alsina M, Cervantes A,Leong T,Lordick F, Nilsson M,van Greeken NCT, Vogel A,Smyth EC; ESMO Guidelines Committee. ESMO Clinical Practice Guidline for diagnosis,treatment and follow-up.Ann Oncol.2022 Oct;33(10):992-1004.<\/h6>\n\n\n\n<ol 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