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2023\u5e742\u6708\uff0c\u72ec\u7acb\u6570\u636e\u76d1\u67e5\u59d4\u5458\u4f1a\uff08IDMC\uff09\u5728\u671f\u4e2d\u5206\u6790\u65f6\u5224\u5b9aTORCHLIGHT\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u8fbe\u5230\u65b9\u6848\u9884\u8bbe\u7684\u4f18\u6548\u754c\u503c\uff0c\u6210\u4e3a\u56fd\u5185\u9996\u4e2a\u5728\u665a\u671fTNBC\u514d\u75ab\u6cbb\u7597\u9886\u57df\u53d6\u5f97\u9633\u6027\u7ed3\u679c\u7684III\u671f\u6ce8\u518c\u7814\u7a76\u3002<\/p>\n\n\n\n
2024\u5e741\u6708\uff0c\u56fd\u9645\u9876\u5c16\u533b\u5b66\u671f\u520a\u300a\u81ea\u7136-\u533b\u5b66\u300b\uff08Nature Medicine<\/em>\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a82.9\uff09\u53d1\u8868\u4e86TORCHLIGHT\u7814\u7a76\u671f\u4e2d\u5206\u6790\u6570\u636e\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u6ce8\u5c04\u7528\u7d2b\u6749\u9187\uff08\u767d\u86cb\u767d\u7ed3\u5408\u578b\uff09\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u6ce8\u5c04\u7528\u7d2b\u6749\u9187\uff08\u767d\u86cb\u767d\u7ed3\u5408\u578b\uff09\u7528\u4e8e\u9996\u8bcaIV\u671f\u6216\u590d\u53d1\u8f6c\u79fb\u6027TNBC\u60a3\u8005\u53ef\u663e\u8457\u5ef6\u957fPD-L1\u9633\u6027\u4eba\u7fa4\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4e5f\u8fbe\u5230\u4e86\u83b7\u76ca\u8d8b\u52bf\uff0c\u5b9e\u73b0\u4e86\u4e2d\u56fd\u665a\u671fTNBC\u514d\u75ab\u6cbb\u7597\u96f6\u7684\u7a81\u7834\u3002\u5176\u4e2d\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7ec4\u7684\u4e2d\u4f4dPFS\u8fbe8.4\u4e2a\u6708\uff0c\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e35%\uff08P=0.0102\uff09\uff1b\u7279\u745e\u666e\u5229\u5355\u6297\u7ec4\u7684\u4e2d\u4f4dOS\u5ef6\u957f\u4e8613.3\u4e2a\u6708\uff0832.8\u4e2a\u6708 vs 19.5\u4e2a\u6708\uff09\uff0c\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8638%\uff08P=0.0148\uff09\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u5b89\u5168\u6027\u6570\u636e\u4e0e\u5df2\u77e5\u98ce\u9669\u76f8\u7b26\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002<\/p>\n\n\n\n
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1. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024 May-Jun;74(3):229-263. doi: 10.3322\/caac.21834. Epub 2024 Apr 4. PMID: 38572751.<\/h6>\n\n\n\n
2. Https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf.<\/h6>\n\n\n\n
3. Dass, S.A., et al. Medicina. 2021; 57, 62.<\/h6>\n\n\n\n
4. De Laurentiis M, et al. Cancer Treat Rev. 2010;36 Suppl 3:S80-6.<\/h6>\n\n\n\n
5. Zeichner SB, et al. Breast Cancer (Auckl). 2016;10:25-36.<\/h6>\n\n\n\n
6. Zefei J, et al. Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial. Nat Med 30, 249\u2013256 (2024).
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