{"id":2554,"date":"2023-11-23T08:00:00","date_gmt":"2023-11-23T00:00:00","guid":{"rendered":"https:\/\/www.junshipharma.com\/?p=2554"},"modified":"2024-01-03T17:55:03","modified_gmt":"2024-01-03T09:55:03","slug":"%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e6%96%b0%e5%86%a0%e5%8f%a3%e6%9c%8d%e8%8d%af%e6%b0%91%e5%be%97%e7%bb%b4%e7%ac%ac2%e9%a1%b9%e4%b8%89%e6%9c%9f%e7%a0%94%e7%a9%b6%e7%bb%93%e6%9e%9c%e8%8d%a3","status":"publish","type":"post","link":"https:\/\/www.junshipharma.com\/%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e6%96%b0%e5%86%a0%e5%8f%a3%e6%9c%8d%e8%8d%af%e6%b0%91%e5%be%97%e7%bb%b4%e7%ac%ac2%e9%a1%b9%e4%b8%89%e6%9c%9f%e7%a0%94%e7%a9%b6%e7%bb%93%e6%9e%9c%e8%8d%a3\/","title":{"rendered":"\u541b\u5b9e\u751f\u7269\u65b0\u51a0\u53e3\u670d\u836f\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u7b2c2\u9879\u4e09\u671f\u7814\u7a76\u7ed3\u679c\u8363\u767b\u300a\u67f3\u53f6\u5200-\u611f\u67d3\u75c5\u5b66\u300b"},"content":{"rendered":"\n<p>\u5317\u4eac\u65f6\u95f42023\u5e7411\u670823\u65e5\uff0c\u56fd\u9645\u611f\u67d3\u75c5\u5b66\u671f\u520a\u6392\u540d\u7b2c\u4e00\u7684\u300a\u67f3\u53f6\u5200-\u611f\u67d3\u75c5\u5b66\u300b\uff08<em>The Lancet Infectious Diseases<\/em>\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a56.3\uff09\u53d1\u5e03\u4e86\u56fd\u4ea7\u65b0\u51a0\u53e3\u670d\u836f\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\uff08\u6c22\u6eb4\u9178\u6c18\u745e\u7c73\u5fb7\u97e6\u7247\uff0c\u4ea7\u54c1\u4ee3\u53f7\uff1aVV116\/JT001\uff09\u7684\u4e00\u9879\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u5b8c\u6574\u6570\u636e\u3002\u636e\u4e86\u89e3\uff0c\u8fd9\u662f\u9996\u4e2a\u5728\u56fd\u9645\u9876\u7ea7\u533b\u5b66\u671f\u520a\u53d1\u8868\u7684\u56fd\u4ea7\u65b0\u51a0\u53e3\u670d\u836f\u2162\u671f\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\uff0c\u4e5f\u662f\u7ee72022\u5e74\u5e95\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u5b9e\u73b0\u9996\u4e2a\u4e2d\u56fd\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u51a0\u521b\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u9996\u767b\u56fd\u9645\u9876\u7ea7\u533b\u5b66\u671f\u520a\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff08<em>NEJM<\/em>\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a158.5\uff09\u4e4b\u540e\uff0c\u7b2c\u4e8c\u9879\u83b7\u5f97\u56fd\u9645\u5b66\u672f\u754c\u8ba4\u53ef\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u57fa\u4e8e\u8be5\u7814\u7a76\uff0c\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u5df2\u4e8e\u4eca\u5e741\u6708\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u8f7b\u3001\u4e2d\u5ea6COVID-19\u6210\u5e74\u60a3\u8005\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1152\" height=\"492\" src=\"https:\/\/www.junshipharma.com\/wp-content\/uploads\/2023\/12\/Lancet-Infec-Dis.jpg\" alt=\"\" class=\"wp-image-2555\"\/><figcaption class=\"wp-element-caption\">\u6765\u6e90\uff1a<em>The Lancet Infectious Diseases<\/em>\u5b98\u7f51<\/figcaption><\/figure>\n\n\n\n<p>\u672c\u6b21\u53d1\u8868\u57fa\u4e8e\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff08NCT05582629\uff09\uff0c\u7531\u6d59\u6c5f\u5927\u5b66\u4f20\u67d3\u75c5\u8bca\u6cbb\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u4e3b\u4efb\u674e\u5170\u5a1f\u9662\u58eb\u7275\u5934\uff0c\u5728\u5168\u56fd31\u5bb6\u4e2d\u5fc3\u5f00\u5c55\u3002\u674e\u5170\u5a1f\u9662\u58eb\u4e3a\u8bba\u6587\u7684\u901a\u8baf\u4f5c\u8005\uff0c\u4e0a\u6d77\u5e02\u516c\u5171\u536b\u751f\u4e34\u5e8a\u4e2d\u5fc3\u8303\u5c0f\u7ea2\u6559\u6388\u548c\u51cc\u4e91\u6559\u6388\uff0c\u6d59\u6c5f\u6811\u4eba\u5927\u5b66\u6811\u5170\u56fd\u9645\u533b\u5b66\u9662\u9644\u5c5e\u6811\u5170\uff08\u676d\u5dde\uff09\u533b\u9662\u6234\u971e\u7ea2\u6559\u6388\u3001\u5434\u4e3d\u82b1\u6559\u6388\u548c\u6c64\u7075\u73b2\u6559\u6388\u4f5c\u4e3a\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3002<\/p>\n\n\n\n<p>\u8be5\u7814\u7a76\u5728\u671f\u4e2d\u5206\u6790\u9636\u6bb5\u5373\u5df2\u83b7\u5f97\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u663e\u8457\u7ed3\u679c\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u6cbb\u7597\u8f7b\u3001\u4e2d\u5ea6\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u6210\u4eba\u60a3\u8005\uff08\u226518\u5c81\uff09\u53ef\u663e\u8457\u7f29\u77ed\u54b3\u55fd\u3001\u6d41\u6d95\u3001\u53d1\u70ed\u3001\u8179\u6cfb\u7b4911\u9879\u4e34\u5e8a\u75c7\u72b6\u7684\u6d88\u5931\u65f6\u95f4\uff0c\u4e2d\u4f4d\u65f6\u95f4\u6bd4\u5b89\u6170\u5242\u7ec4\u7f29\u77ed2\u5929\uff08HR=1.21\uff0cP=0.0023)\u3002\u6700\u7ec8\u5206\u6790\u7ed3\u679c\u4e0e\u671f\u4e2d\u5206\u6790\u4e00\u81f4\uff0c\u75c7\u72b6\u6d88\u5931\u4e2d\u4f4d\u65f6\u95f4\u6bd4\u5b89\u6170\u5242\u7ec4\u7f29\u77ed2\u5929\uff08HR=1.17\uff0cP=0.0009)\uff0c\u4e3a\u56fd\u5185\u5916\u65b0\u51a0\u53e3\u670d\u836f\u5df2\u62a5\u9053\u6570\u636e\u4e2d\u8868\u73b0\u6700\u4f18\uff0c\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u7684\u7597\u6548\u83b7\u76ca\u300260\u5c81\u4ee5\u4e0a\u8001\u5e74\u60a3\u8005\u7684\u4e9a\u7ec4\u5206\u6790\u6570\u636e\u4e0e\u6574\u4f53\u4eba\u7fa4\u4e00\u81f4\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1252\" height=\"600\" src=\"https:\/\/www.junshipharma.com\/wp-content\/uploads\/2024\/01\/\u81f3\u6301\u7eed2\u5929\u75c7\u72b6\u8bc4\u5206\u4e3a0.jpg\" alt=\"\" class=\"wp-image-2576\"\/><figcaption class=\"wp-element-caption\">\u81f3\u6301\u7eed2\u5929\u4e34\u5e8a\u75c7\u72b6\u6d88\u5931\u65f6\u95f4<\/figcaption><\/figure>\n\n\n\n<p>\u6b64\u5916\uff0c\u622a\u81f3\u7ed9\u836f\u7b2c5\u5929\uff0c\u63a5\u53d7\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u6cbb\u7597\u7684\u60a3\u8005\u75c5\u6bd2\u8f6c\u9634\u6bd4\u4f8b\u660e\u663e\u9ad8\u4e8e\u5b89\u6170\u5242\u7ec4\uff0841.6% vs 31.1%\uff0cP<0.0001\uff09\uff0c\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u7ec4\u7684\u75c5\u6bd2Ct\u503c\u4e0a\u5347\u901f\u5ea6\u4ee5\u53ca\u75c5\u6bd2\u8f7d\u91cf\u4e0b\u964d\u901f\u5ea6\u4e5f\u8f83\u5b89\u6170\u5242\u7ec4\u66f4\u5feb\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u65e0\u8bba\u60a3\u8005\u662f\u5426\u4f34\u6709\u8fdb\u5c55\u4e3a\u91cd\u75c7\u7684\u9ad8\u98ce\u9669\u56e0\u7d20\uff0c\u6216\u662f\u5426\u63a5\u79cd\u8fc7\u65b0\u51a0\u75ab\u82d7\uff0c\u5747\u53ef\u5b9e\u73b0\u660e\u663e\u83b7\u76ca\u3002\u7814\u7a76\u671f\u95f4\uff0c\u5b89\u6170\u5242\u7ec4\u67091\u4f8b\u60a3\u8005\u8fdb\u5c55\u4e3a\u91cd\u75c7\uff0c\u800c\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u7ec4\u6ca1\u6709\u60a3\u8005\u8fdb\u5c55\u4e3a\u91cd\u75c7\uff0c\u4e24\u7ec4\u5747\u672a\u51fa\u73b0\u6b7b\u4ea1\u3002\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u5728\u5404\u4eba\u7fa4\u4e2d\uff08\u5305\u62ec\u8001\u5e74\u60a3\u8005\uff09\u7684\u5b89\u5168\u6027\u826f\u597d\uff0c\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u53d1\u751f\u7387\u4e0e\u5b89\u6170\u5242\u76f8\u4f3c\u3002<\/p>\n\n\n\n<p>\u672c\u6b21\u8bd5\u9a8c\u7684\u7814\u7a76\u5bf9\u8c61\u540c\u65f6\u7eb3\u5165\u4e86\u666e\u901a\u4eba\u7fa4\u548c\u4f34\u6709\u8fdb\u5c55\u4e3a\u91cd\u75c7\u7684\u9ad8\u98ce\u9669\u56e0\u7d20\u4eba\u7fa4\uff0c\u4e5f\u8986\u76d6\u4e86\u4e0d\u540c\u7684\u5965\u5bc6\u514b\u620e\u53d8\u5f02\u682a\uff0c\u80fd\u591f\u66f4\u52a0\u5168\u9762\u3001\u5ba2\u89c2\u5730\u4f53\u73b0\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u5728\u73b0\u5b9e\u573a\u666f\u4e2d\u7684\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\u3002\u5728\u7eb3\u5165\u4e3b\u5206\u6790\u96c6\u76841296\u4f8b\uff08\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u7ec4646\u4f8b\uff0c\u5b89\u6170\u5242\u7ec4650\u4f8b\uff09\u60a3\u8005\u4e2d\uff0c\u4e2d\u4f4d\u5e74\u9f84\u4e3a35.0\u5c81\uff0c\u6709558\u4f8b\uff0843.1%\uff09\u60a3\u8005\u4f34\u6709\u9ad8\u98ce\u9669\u56e0\u7d20\u3002\u7814\u7a76\u5165\u7ec4\u671f\u95f4\u8fdb\u884c\u7684\u75c5\u6bd2\u9057\u4f20\u53d8\u5f02\u68c0\u6d4b\u7ed3\u679c\u663e\u793a\uff0c\u60a3\u8005\u611f\u67d3\u7684\u5965\u5bc6\u514b\u620e\u53d8\u5f02\u682a\u4ee5BA.5.2.48\u548cBF.7.14\u4e3a\u4e3b\u8981\u53d8\u4f53\u4e9a\u578b\u3002<\/p>\n\n\n\n<p>\u7efc\u5408\u6b64\u524d\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u53d1\u8868\u7684\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u201c\u5934\u5bf9\u5934\u201d\u5bf9\u6bd43CL\u6291\u5236\u5242\u201cP\u836f\u201d\uff08\u5948\u739b\u7279\u97e6\u7247\/\u5229\u6258\u90a3\u97e6\u7247\u7ec4\u5408\u5305\u88c5\uff09\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff08NCT05341609\uff09\u6210\u679c\uff0c\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u5177\u6709\u975e\u5e38\u660e\u786e\u7684\u6297\u75c5\u6bd2\u6548\u679c\uff0c\u80fd\u591f\u6709\u6548\u6cbb\u7597\u4f34\u6216\u4e0d\u4f34\u6709\u8fdb\u5c55\u4e3a\u91cd\u75c7\u7684\u9ad8\u98ce\u9669\u56e0\u7d20\u7684\u8f7b\u3001\u4e2d\u5ea6COVID-19\u6210\u4eba\u60a3\u8005\uff0c\u53ef\u663e\u8457\u52a0\u901f\u75c7\u72b6\u7f13\u89e3\u548c\u6d88\u5931\u3001\u7f29\u77ed\u75c5\u7a0b\uff0c\u4e14\u76f8\u8f83P\u836f\u7684\u9002\u7528\u4eba\u7fa4\u66f4\u5e7f\uff0c\u5c24\u5176\u662f\u5bf9\u4e8e\u56e0\u60a3\u6709\u5408\u5e76\u75c7\u9700\u8981\u670d\u7528\u591a\u79cd\u836f\u7269\u7684\u60a3\u8005\uff0c\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u7684\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u66f4\u5c11\u3002<\/p>\n\n\n\n<p><strong>\u541b\u5b9e\u751f\u7269\u5168\u7403\u7814\u53d1\u603b\u88c1\u90b9\u5efa\u519b\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5305\u62ec\u591a\u9879\u56fd\u5185\u5916\u5927\u578b\u2162\u671f\u7814\u7a76\u5728\u5185\uff0c\u5168\u7403\u5df2\u6709\u8d85\u8fc73000\u4f8b\u60a3\u8005\u53c2\u4e0e\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u7684\u7814\u7a76\uff0c\u4e3a\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u5728\u66f4\u5e7f\u6cdb\u4eba\u7fa4\u4e2d\u7684\u5e94\u7528\u63d0\u4f9b\u4e86\u624e\u5b9e\u7684\u6570\u636e\u652f\u6301\uff0c\u4e5f\u8ba9\u8be5\u836f\u7269\u6210\u4e3a\u76ee\u524d\u5faa\u8bc1\u8bc1\u636e\u6700\u5145\u5206\u7684\u56fd\u4ea7\u65b0\u51a0\u53e3\u670d\u836f\u4e4b\u4e00\u3002\u4e00\u5e74\u5185\u4e24\u6b21\u767b\u4e0a\u56fd\u9645\u9876\u7ea7\u533b\u5b66\u671f\u520a\uff0c\u662f\u5bf9\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\u7814\u7a76\u56e2\u961f\u7684\u79d1\u7814\u6c34\u5e73\u3001\u7814\u53d1\u8d28\u91cf\u7684\u9ad8\u5ea6\u8ba4\u53ef\uff0c\u6211\u4eec\u5bf9\u6b64\u611f\u5230\u975e\u5e38\u81ea\u8c6a\u3002\u56fd\u4ea7\u65b0\u51a0\u521b\u65b0\u836f\u7684\u5d1b\u8d77\uff0c\u662f\u6211\u56fd\u533b\u836f\u4ea7\u4e1a\u521b\u65b0\u53d1\u5c55\u6210\u679c\u7684\u91cd\u8981\u4f53\u73b0\u4e4b\u4e00\uff0c\u662f\u5bf9\u4fdd\u969c\u4eba\u6c11\u7fa4\u4f17\u751f\u547d\u5b89\u5168\u548c\u8eab\u4f53\u5065\u5eb7\u7684\u6709\u529b\u8df5\u884c\u3002\u541b\u5b9e\u751f\u7269\u5c06\u643a\u624b\u5404\u65b9\u7ee7\u7eed\u524d\u884c\uff0c\u52a9\u529b\u4ea7\u4e1a\u53d1\u5c55\u3001\u9020\u798f\u66f4\u591a\u60a3\u8005\uff01\u201d<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u3010\u53c2\u8003\u6587\u732e\u3011<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\">1. Xiaohong Fan, Xiahong Dai, Yun Ling, et al. Oral VV116 versus placebo in patients with mild-to-moderate COVID-19 in China: a multicentre, double-blind, phase 3, randomised controlled study. The Lancet Infectious Diseases. DOI:10.1016\/S1473-3099(23)00577-7.<\/h5>\n\n\n\n<p><\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><em>1. <em>\u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/em><\/h6>\n\n\n\n<h6 class=\"wp-block-heading\"><em>2. <em>\u82e5\u60a8\u60f3\u4e86\u89e3\u5177\u4f53\u75be\u75c5\u8bca\u7597\u4fe1\u606f\uff0c\u8bf7\u9075\u4ece\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u4e0e\u6307\u5bfc\u3002<\/em><\/em><\/h6>\n\n\n\n<p><\/p>\n\n\n\n<p><strong><strong><strong>\u5173\u4e8e\u6c11\u5f97\u7ef4<sup>\u00ae<\/sup>\uff08\u6c22\u6eb4\u9178\u6c18\u745e\u7c73\u5fb7\u97e6\u7247\uff0cVV116\/JT001\uff09<\/strong><\/strong><\/strong><\/p>\n\n\n\n<p>VV116\u662f\u4e00\u6b3e\u53e3\u670d\u6838\u82f7\u7c7b\u836f\u7269\uff0c\u53ef\u6291\u5236SARS-CoV-2\u590d\u5236\u3002\u4e34\u5e8a\u524d\u836f\u6548\u5b66\u7814\u7a76\u663e\u793a\uff0cVV116\u5728\u4f53\u5916\u5bf9\u5305\u62ec\u5965\u5bc6\u514b\u620e\u5728\u5185\u7684\u65b0\u51a0\u75c5\u6bd2\u539f\u59cb\u682a\u548c\u7a81\u53d8\u682a\u8868\u73b0\u51fa\u663e\u8457\u7684\u6297\u75c5\u6bd2\u4f5c\u7528\uff1b\u5728\u5c0f\u9f20\u6a21\u578b\u4e0a\uff0c\u4f4e\u5242\u91cf\u7684VV116\u5c31\u53ef\u5c06\u80ba\u90e8\u75c5\u6bd2\u6ef4\u5ea6\u964d\u4f4e\u81f3\u68c0\u6d4b\u9650\u4ee5\u4e0b\uff0c\u53ef\u663e\u8457\u6539\u5584\u80ba\u7ec4\u7ec7\u75c5\u7406\u53d8\u5316\uff0c\u8868\u73b0\u51fa\u8f83\u5f3a\u7684\u6297\u75c5\u6bd2\u529f\u6548\u3002\u4e34\u5e8a\u524d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7b49\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0cVV116\u5177\u6709\u5f88\u9ad8\u7684\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5176\u53e3\u670d\u5438\u6536\u540e\uff0c\u8fc5\u901f\u4ee3\u8c22\u4e3a\u6bcd\u4f53\u6838\u82f7\uff0c\u5e76\u5728\u4f53\u5185\u7ec4\u7ec7\u5e7f\u6cdb\u5206\u5e03\u3002<\/p>\n\n\n\n<p>VV116\u7531\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u6b66\u6c49\u75c5\u6bd2\u7814\u7a76\u6240\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u65b0\u7586\u7406\u5316\u6280\u672f\u7814\u7a76\u6240\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u4e2d\u4e9a\u836f\u7269\u7814\u53d1\u4e2d\u5fc3\/\u4e2d\u4e4c\u533b\u836f\u79d1\u6280\u57ce\uff08\u79d1\u6280\u90e8\u201c\u4e00\u5e26\u4e00\u8def\u201d\u8054\u5408\u5b9e\u9a8c\u5ba4\uff09\u3001\u4e34\u6e2f\u5b9e\u9a8c\u5ba4\u3001\u82cf\u5dde\u65fa\u5c71\u65fa\u6c34\u751f\u7269\u533b\u836f\u6709\u9650\u516c\u53f8\uff08\u65fa\u5c71\u65fa\u6c34\uff09\u548c\u541b\u5b9e\u751f\u7269\u5171\u540c\u7814\u53d1\u3002<\/p>\n\n\n\n<p>\u5728\u65b0\u51a0\u75ab\u60c5\u671f\u95f4\uff0cVV116\u5f00\u5c55\u4e86\u591a\u9879\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c\u3002 1\u9879\u5728\u4f34\u6709\u8fdb\u5c55\u4e3a\u91cd\u75c7\u9ad8\u98ce\u9669\u56e0\u7d20\u7684\u8f7b\u4e2d\u5ea6COVID-19\u60a3\u8005\u4e2d\u5bf9\u6bd4PAXLOVID\u7528\u4e8e\u8f7b\u4e2d\u5ea6COVID-19\u65e9\u671f\u6cbb\u7597\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff08JT001-010\uff09\u83b7\u5f97\u56fd\u9645\u6743\u5a01\u671f\u520a\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff08<em>The New England Journal of Medicine<\/em>\uff09\u53d1\u8868<sup>[1]<\/sup>\uff0c\u53e61\u9879\u5728\u4f34\u6216\u4e0d\u4f34\u6709\u8fdb\u5c55\u4e3a\u91cd\u75c7\u9ad8\u98ce\u9669\u56e0\u7d20\u7684\u8f7b\u4e2d\u5ea6COVID-19\u60a3\u8005\u4e2d\u5f00\u5c55\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff08JT001-015\uff09\u83b7\u5f97\u56fd\u9645\u9876\u5c16\u611f\u67d3\u75c5\u5b66\u671f\u520a\u300a\u67f3\u53f6\u5200-\u611f\u67d3\u75c5\u5b66\u300b\uff08<em>The Lancet Infectious Diseases<\/em>\uff09\u53d1\u8868<sup>[2]<\/sup>\u3002<\/p>\n\n\n\n<p>2021\u5e7412\u6708\uff0cVV116\u5728\u4e4c\u5179\u522b\u514b\u65af\u5766\u83b7\u5f97\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u4e2d\/\u91cd\u5ea6COVID-19\u60a3\u8005\u3002<\/p>\n\n\n\n<p>2023\u5e741\u6708\uff0cVV116\u5728\u4e2d\u56fd\u83b7\u5f97\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u8f7b\u4e2d\u5ea6COVID-19\u7684\u6210\u5e74\u60a3\u8005\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u3010\u53c2\u8003\u6587\u732e\u3011<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\">1. Cao Z, Gao W, Bao H, et al. VV116 versus Nirmatrelvir\u2013Ritonavir for Oral Treatment of Covid-19. N Engl J Med. DOI: 10.1056\/NEJMoa2208822.<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\">2. Xiaohong Fan, Xiahong Dai, Yun Ling, et al. Oral VV116 versus placebo in patients with mild-to-moderate COVID-19 in China: a multicentre, double-blind, phase 3, randomised controlled study. The Lancet Infectious Diseases. DOI:10.1016\/S1473-3099(23)00577-7.<\/h5>\n","protected":false},"excerpt":{"rendered":"<p>\u5317\u4eac\u65f6\u95f42023\u5e7411\u670823\u65e5\uff0c\u56fd\u9645\u611f\u67d3\u75c5\u5b66\u671f\u520a\u6392\u540d\u7b2c\u4e00\u7684\u300a\u67f3\u53f6\u5200-\u611f\u67d3\u75c5\u5b66\u300b\uff08The Lancet Infectious Diseases\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a56.3\uff09\u53d1\u5e03\u4e86\u56fd\u4ea7\u65b0\u51a0\u53e3\u670d\u836f\u6c11\u5f97\u7ef4\u00ae\uff08\u6c22\u6eb4\u9178\u6c18\u745e\u7c73\u5fb7\u97e6\u7247\uff0c\u4ea7\u54c1\u4ee3\u53f7\uff1aVV116\/JT001\uff09\u7684\u4e00\u9879\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u5b8c\u6574\u6570\u636e\u3002<\/p>\n","protected":false},"author":3,"featured_media":2555,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2554","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1"],"yoast_head":"<!-- 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