{"id":1689,"date":"2021-11-29T07:54:16","date_gmt":"2021-11-29T07:54:16","guid":{"rendered":"https:\/\/www.junshipharma.com\/?p=1689"},"modified":"2023-01-12T07:57:00","modified_gmt":"2023-01-12T07:57:00","slug":"%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e7%89%b9%e7%91%9e%e6%99%ae%e5%88%a9%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e5%8c%96%e7%96%97%e7%94%a8%e4%ba%8e%e9%bc%bb%e5%92%bd%e7%99%8c%e4%b8%80%e7%ba%bf%e6%b2%bb","status":"publish","type":"post","link":"https:\/\/www.junshipharma.com\/%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e7%89%b9%e7%91%9e%e6%99%ae%e5%88%a9%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e5%8c%96%e7%96%97%e7%94%a8%e4%ba%8e%e9%bc%bb%e5%92%bd%e7%99%8c%e4%b8%80%e7%ba%bf%e6%b2%bb\/","title":{"rendered":"\u541b\u5b9e\u751f\u7269\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7528\u4e8e\u9f3b\u54bd\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u65b0\u9002\u5e94\u75c7\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02"},"content":{"rendered":"\n<p>\u5317\u4eac\u65f6\u95f42021\u5e7411\u670829\u65e5\uff0c\u541b\u5b9e\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u5ba3\u5e03\uff0c\u7531\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u6297PD-1\u5355\u6297\u836f\u7269\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca<sup>\u00ae<\/sup>\uff09\u8054\u5408\u987a\u94c2\u548c\u5409\u897f\u4ed6\u6ee8\u7528\u4e8e\u5c40\u90e8\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u7684\u65b0\u9002\u5e94\u75c7\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u3002<\/p>\n\n\n\n<p>\u8fd9\u662f\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u9f3b\u54bd\u764c\u9886\u57df\u53d6\u5f97\u7684\u7b2c\u4e8c\u9879\u9002\u5e94\u75c7\u3002\u4eca\u5e742\u6708\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\uff08\u62d3\u76ca<sup>\u00ae<\/sup>\uff09\u88ab\u6279\u51c6\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u7cfb\u7edf\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1\/\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\uff08NPC\uff09\u60a3\u8005\u7684\u6cbb\u7597\uff0c\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u83b7\u6279\u9f3b\u54bd\u764c\u6cbb\u7597\u7684\u6297PD-1\u5355\u6297\u3002\u6b64\u6b21\u7279\u745e\u666e\u5229\u5355\u6297\uff08\u62d3\u76ca<sup>\u00ae<\/sup>\uff09\u5728\u9f3b\u54bd\u764c\u4e00\u7ebf\u6cbb\u7597\u201c\u518d\u4e0b\u4e00\u57ce\u201d\uff0c\u5c06\u4e3a\u5904\u4e8e\u4e0d\u540c\u6cbb\u7597\u9636\u6bb5\u7684\u60a3\u8005\u5e26\u6765\u521b\u65b0\u7684\u6cbb\u7597\u65b9\u6848\u548c\u66f4\u957f\u7684\u751f\u5b58\u83b7\u76ca\u3002<\/p>\n\n\n\n<p>\u9f3b\u54bd\u764c\u662f\u4e00\u79cd\u539f\u53d1\u4e8e\u9f3b\u54bd\u90e8\u9ecf\u819c\u4e0a\u76ae\u7684\u6076\u6027\u80bf\u7624\uff0c\u662f\u5e38\u89c1\u7684\u5934\u9888\u90e8\u80bf\u7624\u4e4b\u4e00\u3002\u636e\u7edf\u8ba1\uff0c2020\u5e74\u5168\u7403\u9f3b\u54bd\u764c\u65b0\u53d1\u75c5\u4f8b\u6570\u8d85\u8fc713\u4e07<a href=\"#_ftn1\" id=\"_ftnref1\">[1]<\/a>\uff0c\u5176\u4e2d\u8fd1\u534a\u6570\u75c5\u4f8b\u5728\u4e2d\u56fd<a href=\"#_ftn2\" id=\"_ftnref2\">[2]<\/a>\u3002\u4e2d\u56fd\u5357\u65b9\uff08\u5982\u5e7f\u4e1c\u3001\u5e7f\u897f\uff09\u548c\u4e1c\u5357\u4e9a\u5730\u533a\u9ad8\u53d1<a href=\"#_ftn3\" id=\"_ftnref3\">[3]<\/a>\u3002\u5bf9\u4e8e\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\uff0c\u76ee\u524d\u7684\u6cbb\u7597\u624b\u6bb5\u6709\u9650\uff0c\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u662f\u4ee5\u94c2\u7c7b\u4e3a\u57fa\u7840\u7684\u4e24\u836f\u8054\u5408\u5316\u7597\uff0c\u4f46\u6cbb\u7597\u540e\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u65f6\u95f4\u4ec5\u67097\u4e2a\u6708\u5de6\u53f3<a href=\"#_ftn4\" id=\"_ftnref4\">[4]<\/a>\u3002<\/p>\n\n\n\n<p>\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f90\u745e\u534e\u6559\u6388\u56e2\u961f\u4e0e\u672c\u571f\u521b\u65b0\u836f\u4f01\u541b\u5b9e\u751f\u7269\u5408\u4f5c\uff0c\u81ea2016\u5e74\u8d77\u63a2\u7d22\u65b0\u5174\u514d\u75ab\u7597\u6cd5\u4e0e\u4f20\u7edf\u5316\u7597\u76f8\u7ed3\u5408\u7684\u521b\u65b0\u578b\u4e34\u5e8a\u65b9\u6848\uff0c\u5f00\u5c55\u540e\u7ebf\u81f3\u4e00\u7ebf\u6cbb\u7597\u201c\u5168\u7ebf\u8d2f\u7a7f\u201d\u7684\u4e34\u5e8a\u5e03\u5c40\u3002\u4eceIb\/II\u671f\u7684\u5c0f\u6837\u672c\u91cf\u63a2\u7d22\u6027\u7814\u7a76\u3001II\u671f\u514d\u75ab\u5355\u836f\u4e8c\u7ebf\u53ca\u540e\u7ebf\u6cbb\u7597\u7684POLARIS-02\u7814\u7a76\uff0c\u518d\u5230\u9996\u521b\u5168\u7403\u89c4\u6a21\u6700\u5927\u7684\u56fd\u9645\u591a\u4e2d\u5fc3\u201c\u514d\u75ab\u6cbb\u7597+\u5316\u7597\u201d\u4e00\u7ebf\u6cbb\u7597\u7684JUPITER-02\u7814\u7a76\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\uff08\u62d3\u76ca<sup>\u00ae<\/sup>\uff09\u5728\u9f3b\u54bd\u764c\u6cbb\u7597\u9886\u57df\u53d6\u5f97\u4e86\u624e\u5b9e\u7684\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u3002<\/p>\n\n\n\n<p>\u6b64\u6b21\u65b0\u9002\u5e94\u75c7\u7684\u83b7\u6279\u57fa\u4e8eJUPITER-02\u7814\u7a76\uff08NCT03581786\uff09\uff0c\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u56fd\u9645\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u7531<strong>\u5f90\u745e\u534e\u6559\u6388<\/strong>\u62c5\u4efb\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u4e24\u5730\u540c\u65f6\u6ce8\u518c\u3002\u81ea2018\u5e7411\u6708\u81f32019\u5e7410\u6708\uff0cJUPITER-02\u7814\u7a76\u5728\u4e2d\u56fd\u5927\u9646\u3001\u4e2d\u56fd\u53f0\u6e7e\u3001\u65b0\u52a0\u5761\u768435\u5bb6\u7814\u7a76\u4e2d\u5fc3\u5171\u7eb3\u5165289\u4f8b\u672a\u63a5\u53d7\u8fc7\u5316\u7597\u7684\u590d\u53d1\/\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5355\u7eaf\u5316\u7597\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u548c\u987a\u94c2\uff08GP\u5316\u7597\uff09\u4e00\u7ebf\u6cbb\u7597\u590d\u53d1\/\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u53ef\u83b7\u5f97\u66f4\u4f18\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u66f4\u9ad8\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u548c\u66f4\u957f\u7684\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\uff0c\u5b89\u5168\u6027\u53ef\u7ba1\u7406\uff0c\u4e14\u65e0\u8bba\u60a3\u8005PD-L1\u8868\u8fbe\u5982\u4f55\uff0c\u5747\u53ef\u83b7\u76ca\u3002\u622a\u81f3\u671f\u4e2d\u5206\u6790\u65e5\uff082020\u5e745\u670830\u65e5\uff09\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u7684\u4e2d\u4f4dPFS\u8fbe\u523011.7\u4e2a\u6708\uff0c\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7ec4\u5ef6\u957f3.7\u4e2a\u6708\uff08HR=0.52 [95\uff05CI\uff1a0.36-0.74]\uff0c\u53cc\u4fa7p=0.0003\uff09\uff1b\u5c06\u8fd1\u4e00\u534a\u60a3\u8005\u8d85\u8fc7\u4e00\u5e74\u8fd8\u6ca1\u6709\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\uff0c\u6bd4\u5b89\u6170\u5242\u7ec4\u591a21.5%\uff0c\u4ee3\u8868\u6709\u66f4\u591a\u60a3\u8005\u83b7\u76ca\uff1bORR\u4e3a77.4% vs 66.4%\uff08P=0.033\uff09\uff0c\u4e2d\u4f4dDoR\u4e3a10.0 vs 5.7\u4e2a\u6708\uff08HR = 0.50 [95\uff05CI\uff1a0.33-0.78]\uff09\uff0c\u6bd4\u5b89\u6170\u5242\u7ec4\u5ef6\u957f\u8fd11\u500d\uff1b\u76ee\u524d\u4e2d\u4f4d\u603b\u751f\u5b58\uff08OS\uff09\u4ecd\u672a\u6210\u719f\uff0c\u4e0d\u8fc7\u5df2\u89c2\u5bdf\u5230\u7279\u745e\u666e\u5229\u5355\u6297\u7ec4\u603b\u751f\u5b58\u7684\u83b7\u76ca\u8d8b\u52bf\uff0c\u5176\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8640%\u3002<\/p>\n\n\n\n<p>\u4f5c\u4e3a\u8fc4\u4eca\u4e3a\u6b62\u5168\u7403\u8303\u56f4\u5185\u89c4\u6a21\u6700\u5927\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff0cJUPITER-02\u7814\u7a76\u591a\u6b21\u83b7\u5f97\u56fd\u9645\u5b66\u754c\u9ad8\u5ea6\u5173\u6ce8\uff0c\u66fe\u4ee5\u201c\u91cd\u78c5\u7814\u7a76\u6458\u8981\u201d\u5f62\u5f0f\uff08#LBA2\uff09\u5165\u9009\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\uff08ASCO 2021\uff09\u5168\u4f53\u5927\u4f1a\uff0c\u5e76\u57282021\u5e749\u6708\u4ee5\u5c01\u9762\u63a8\u8350\u5f62\u5f0f\u520a\u767b\u5728SCI\u5f71\u54cd\u56e0\u5b50\u6392\u540d\u524d20\u4f4d\u7684\u56fd\u9645\u9876\u5c16\u671f\u520a\u300a\u81ea\u7136-\u533b\u5b66\u300b\u6742\u5fd7\uff08<em>Nature Medicine<\/em>\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a53.440\uff09\uff0c\u8fd9\u4e5f\u662f\u300a\u81ea\u7136-\u533b\u5b66\u300b\u521b\u520a26\u5e74\u6765\u9996\u6b21\u5728\u5c01\u9762\u4e0a\u63a8\u8350\u4e2d\u56fd\u521b\u65b0\u836f\u7269\u7814\u7a76\u3002<\/p>\n\n\n\n<p>\u57fa\u4e8e\u7279\u745e\u666e\u5229\u5355\u6297\u5728POLARIS-02\u548cJUPITER-02\u4e24\u9879\u7814\u7a76\u4e2d\u53d6\u5f97\u7684\u5353\u8d8a\u6210\u679c\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u8be5\u836f\u54c12\u9879\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u65e8\u5728\u52a0\u901f\u5176\u5f00\u53d1\u548c\u5ba1\u8bc4\u7a0b\u5e8f\u3002\u76ee\u524d\uff0c\u541b\u5b9e\u751f\u7269\u5df2\u5411FDA\u63d0\u4ea4\u4e86\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5409\u897f\u4ed6\u6ee8\/\u987a\u94c2\u4f5c\u4e3a\u665a\u671f\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u548c\u5355\u836f\u7528\u4e8e\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u542b\u94c2\u6cbb\u7597\u540e\u7684\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\u7684\u4e24\u9879\u9002\u5e94\u75c7\u7684\u751f\u7269\u5236\u54c1\u8bb8\u53ef\u7533\u8bf7\uff08BLA\uff09\u5e76\u83b7\u53d7\u7406\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u4e5f\u662f\u9996\u4e2a\u5411FDA\u63d0\u4ea4BLA\u7684\u56fd\u4ea7\u6297PD-1\u5355\u6297\u3002<\/p>\n\n\n\n<p>\u201c\u81f4\u529b\u653b\u514b\u9f3b\u54bd\u764c\u8fd9\u7c7b\u4e34\u5e8a\u9700\u6c42\u5728\u4e2d\u56fd\u5c24\u4e3a\u7a81\u51fa\u7684\u75be\u75c5\uff0c\u6211\u4eec\u672c\u571f\u7814\u7a76\u8005\u8d23\u65e0\u65c1\u8d37\u3002\u7ecf\u8fc7\u8fc7\u53bb5\u5e74\u7684\u6301\u7eed\u63a2\u7d22\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u6210\u529f\u9a8c\u8bc1\u4e86\u4ece\u540e\u7ebf\u81f3\u4e00\u7ebf\u6cbb\u7597\u590d\u53d1\/\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u7684\u5353\u8d8a\u7597\u6548\uff0c\u5b9e\u73b0\u4e86\u514d\u75ab\u6cbb\u7597\u5728\u9f3b\u54bd\u764c\u9886\u57df\u7a81\u7834\u6027\u8fdb\u5c55\u3002\u4e2d\u56fd\u60a3\u8005\u80fd\u591f\u7387\u5148\u53d7\u76ca\u4e8e\u521b\u65b0\u7597\u6cd5\uff0c\u8fd9\u8ba9\u6211\u4eec\u611f\u5230\u5f88\u9a84\u50b2\u3002\u201d<strong>\u5f90\u745e\u534e\u6559\u6388<\/strong>\u8868\u793a\uff1a\u201c\u76f8\u6bd4\u76ee\u524d\u7684\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u80fd\u591f\u4e3a\u60a3\u8005\u5e26\u6765\u66f4\u4f18\u8d8a\u7684\u751f\u5b58\u83b7\u76ca\uff0c\u4e14\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002\u540c\u65f6\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7528\u4e8e\u9f3b\u54bd\u764c\u6cbb\u7597\u7684\u4e24\u9879\u9002\u5e94\u75c7\u6b63\u5728\u7f8e\u56fd\u8fdb\u884c\u4e0a\u5e02\u7533\u8bf7\uff0c\u6211\u4eec\u4e5f\u671f\u5f85\u8fd9\u9879\u4e2d\u56fd\u65b9\u6848\u7684\u51fa\u53f0\u53ef\u4ee5\u4e3a\u5168\u7403\u9f3b\u54bd\u764c\u6cbb\u7597\u6811\u7acb\u65b0\u6807\u51c6\u3002\u201d<\/p>\n\n\n\n<p>\u201c\u4f5c\u4e3a\u5168\u7403\u9996\u6b3e\u9f3b\u54bd\u764c\u514d\u75ab\u6cbb\u7597\u836f\u7269\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u4e34\u5e8a\u8bd5\u9a8c\u60a3\u8005\u548c\u7814\u53d1\u56e2\u961f\u7684\u652f\u6301\u4e0b\u7ee7\u7eed\u6df1\u8015\uff0c\u6b64\u6b21\u5728\u4e00\u7ebf\u6cbb\u7597\u9886\u57df\u53c8\u83b7\u6279\u4e86\u65b0\u7684\u9002\u5e94\u75c7\uff0c\u5c06\u4e3a\u66f4\u591a\u665a\u671f\u9f3b\u54bd\u764c\u60a3\u8005\u63d0\u4f9b\u66f4\u597d\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d<strong>\u541b\u5b9e\u751f\u7269\u9996\u5e2d\u533b\u5b66\u5b98Patricia Keegan\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u541b\u5b9e\u751f\u7269\u6301\u7eed\u5173\u6ce8\u56fd\u4eba\u4e2d\u9ad8\u53d1\uff0c\u4e14\u5bf9\u514d\u75ab\u6cbb\u7597\u6709\u8f83\u597d\u54cd\u5e94\u3001\u4e34\u5e8a\u6025\u9700\u6cbb\u7597\u7684\u7624\u79cd\uff0c\u9488\u5bf9\u9f3b\u54bd\u764c\u5f00\u5c55\u7684POLARIS-02\u548cJUPITER-02\u4e24\u9879\u7814\u7a76\u6b63\u662f\u5176\u4e2d\u9887\u5177\u4ee3\u8868\u6027\u7684\u4f8b\u8bc1\u3002\u6211\u4eec\u6b23\u559c\u5730\u770b\u5230\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u6240\u53d6\u5f97\u7684\u7a81\u7834\u6027\u7ed3\u679c\u4e0d\u4ec5\u4e3a\u4e2d\u56fd\u60a3\u8005\u5e26\u6765\u65b0\u5e0c\u671b\uff0c\u8fd8\u591a\u6b21\u83b7\u5f97\u4e86\u6765\u81ea\u6d77\u5916\u5b66\u672f\u754c\u548c\u76d1\u7ba1\u673a\u6784\u7684\u9ad8\u5ea6\u8ba4\u53ef\uff0c\u5e0c\u671b\u6d77\u5916\u60a3\u8005\u4e5f\u80fd\u5728\u4e0d\u8fdc\u7684\u5c06\u6765\u53d7\u76ca\u4e8e\u6211\u4eec\u7684\u65b0\u836f\u3002\u201d<\/p>\n\n\n\n<p>\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u7b2c\u56db\u9879\u9002\u5e94\u75c7\u5728\u4e2d\u56fd\u83b7\u6279\u3002\u5728\u8fd9\u9879\u4e0e\u5316\u7597\u8054\u5408\u7528\u836f\u7684\u7814\u7a76\u4e2d\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u663e\u793a\u51fa\u4e86\u4f5c\u4e3a\u57fa\u77f3\u7c7b\u836f\u7269\u7684\u6f5c\u529b\uff0c\u6211\u4eec\u671f\u5f85\u672a\u6765\u901a\u8fc7\u66f4\u5e7f\u6cdb\u7684\u514d\u75ab\u8054\u5408\u7597\u6cd5\uff0c\u8ba9\u66f4\u591a\u80bf\u7624\u60a3\u8005\u83b7\u76ca\u3002\u201d<strong>\u541b\u5b9e\u751f\u7269\u9996\u5e2d\u6267\u884c\u5b98\u674e\u5b81\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u540c\u65f6\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u8df5\u884c\u2018\u7acb\u8db3\u4e2d\u56fd\u3001\u5e03\u5c40\u5168\u7403\u2019\u7684\u56fd\u9645\u5316\u6218\u7565\uff0c\u4e3a\u4e2d\u56fd\u9ad8\u53d1\u80bf\u7624\u7684\u6cbb\u7597\u63a2\u7d22\u65b0\u7684\u65b9\u5411\uff0c\u4e3a\u4e16\u754c\u4e34\u5e8a\u7814\u7a76\u8d21\u732e\u4e2d\u56fd\u521b\u65b0\u529b\u91cf\u3002\u201d<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e\uff1a<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><a id=\"_ftn1\" href=\"#_ftnref1\">[1]<\/a> https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/4-Nasopharynx-fact-sheet.pdf.<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><a href=\"#_ftnref2\" id=\"_ftn2\">[2]<\/a> https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf.<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><a href=\"#_ftnref3\" id=\"_ftn3\">[3]<\/a> Chen YP, et al. Lancet 2019.394:64-80,<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><a id=\"_ftn4\" href=\"#_ftnref4\">[4]<\/a> 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